Publications
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* denotes equal contribution
# denotes corresponding author/s
# denotes corresponding author/s
2020
35. M.T. Doolin*, R.A. Moriarty*, and K.M. Stroka#. Mechanosensing of Physical Confinement by Mesenchymal-Like Cells, Frontiers in Physiology, accepted (2020). (*, equal contribution)
*** invited manuscript for special issue on “Mechanosensing at Biointerfaces.”
34. K.M. Gray, J.W. Jung, C.T. Inglut, H.-C. Huang, and K.M. Stroka#. Quantitatively relating brain endothelial cell-cell junction phenotype to global and local barrier properties under varied culture conditions via the Junction Analyzer Program, Fluids and Barriers of the CNS 17(1): 16 (2020). Link
*** invited manuscript for special issue on "Advances in in vitro modeling of the blood-brain barrier and neurovascular unit."
33. S.P. Ikonomova, P. Moghaddam-Taaherii, Y. Wang, M.T. Doolin, K.M. Stroka, B. Hube, and A.J. Karlsson#. Effects of histatin-5 modifications on antifungal activity and kinetics of proteolysis, Protein Science 29(2): 480-493 (2020). Link
2019
32. M.A. Pranda, B.J. Murugesan, A.J. Knoll, G.S. Oehrlein, and K.M. Stroka#. Sensitivity of tumor vs. normal cell migration and morphology to cold atmospheric plasma-treated media in varying culture conditions, Plasma Processes and Polymers e1900103 (2019). Link
31. Z. Gong, M.T. Doolin, S. Adhikari, K.M. Stroka, A.J. Karlsson#. Role of charge and hydrophobicity in translocation of cell-penetrating peptides into Candida albicans cells, AICheE Journal 65: e16768 (2019). Link.
*** invited manuscript for special issue on “Future of Chemical Engineering.”
30. M.T. Doolin and K.M. Stroka#. Integration of mesenchymal stem cells into a novel micropillar confinement assay, Tissue Engineering Part C: Methods 25(11): 662-676 (2019). Link
*** invited manuscript for special issue on “Methods in Biomechanics and Mechanobiology for Tissue Repair and Regeneration.”
29. M.A. Pranda*, K.M. Gray*, G.M. Dawson, A.J.L. DeCastro, J.W. Jung, and K.M. Stroka#. Tumor cell mechanosensing during incorporation into the brain microvascular endothelium, Cellular and Molecular Bioengineering 12(5):455-480 (2019). (*, equal contribution). Link
*** invited as part of Cellular and Molecular Bioengineering Young Innovator Award special issue.
28. M.T. Doolin*, T.S. Ornstein*, and K.M. Stroka#. Nuclear deformation in response to mechanical confinement is cell type dependent, Cells 8(5): 427 (2019). *, equal contribution) Link
*** invited manuscript for special issue on “Frontiers in Cytoskeleton Research—From Development to Disease.”
27. C. Conrad, K.M. Gray, K.M. Stroka, I. Rizvi, and G. Scarcelli#. Mechanical Characterization of 3D Ovarian Cancer Nodules using Brillouin Confocal Microscopy, Cellular and Molecular Bioengineering 12(3): 215-226 (2019). Link
26. K.M. Gray, D.B. Katz, E.G. Brown, and K.M. Stroka#. Quantitative phenotyping of cell-cell junctions to evaluate ZO-1 presentation in brain endothelial cells, Annals of Biomedical Engineering 47(7): 1675-1687 (2019). Link
2018
25. R.A. Moriarty and K.M. Stroka#. Physical confinement alters sarcoma cell cycle progression and division. Cell Cycle 17(19-20): 2360-2373 (2018). Link
24. M.T. Doolin and K.M. Stroka#. Physical confinement alters cytoskeletal contributions towards human mesenchymal stem cell migration. Cytoskeleton 75:103–117 (2018). Link
*** featured in cover art.
2017
23. M.A. Shumakovich, C.P. Mencio, J.S. Siglin, R.A. Moriarty, H.M. Geller, and K.M. Stroka#. Astrocytes from the brain microenvironment alter migration and morphology of metastatic breast cancer cells, FASEB Journal 31:115049-5067 (2017). Link
22. K.M. Gray and K.M. Stroka#. Vascular endothelial cell mechanosensing: New insights gained from biomimetic microfluidic models, Seminars in Cell and Developmental Biology 71:106-117 (2017). Link
*** invited review article for special issue on “Mechanosensing: from Molecules to Tissues”
21. D.B. Patel*, K.M. Gray*, Y. Santharam, K.M. Stroka#, S.M. Jay#. Effects of cell seeding density and passage number on mesenchymal stem cell exosome biogenesis and vascularization activity, Bioengineering and Translational Medicine, 2:170-179 (2017). Link
20. K.M. Stroka#, B.S. Wong, M. Shriver, J.M. Phillip, D. Wirtz, A. Kontrogianni, and K. Konstantopoulos#. Loss of giant obscurins alters breast epithelial cell mechanosensing of matrix stiffness, Oncotarget 8:54004-54020 (2017). Pubmed ID: 27494856
2015
19. M. Shriver, K.M. Stroka, M. Vitolo, S.S. Martin, D. Huso, K. Konstantopoulos, and A. Kontrogianni#. Loss of giant obscurins from breast epithelium promotes cell migration, invasion, and metastasis, Oncogene 34:4248-4259 (2015). Pubmed ID: 25381817
18. K.M. Stroka#. Leukocyte trans-endothelial migration: A biophysical event. In: Mechanobiology of the Endothelium. (Aranda-Espinoza, ed.) CRC Press, Boca Raton, FL. (2015). CRC Press
2014
17. S. Hamilla*, K.M. Stroka*, and H. Aranda-Espinoza#. VE-cadherin-independent cancer cell incorporation into the vascular endothelium precedes transmigration, PLOS ONE 9(10): e109748 (2014). Pubmed ID: 25275457
16. K.M. Stroka, Z.Gu, S.X. Sun, and K. Konstantopoulos#. Bioengineering paradigms for cell migration in confined microenvironments Current Opinion in Cell Biology 30C: 41-50 (2014) (Invited review). Pubmed ID: 24973724
15. K.M. Stroka*, H. Jiang*, S-H Chen, Z. Tong, D. Wirtz, S.X. Sun#, and K. Konstantopoulos#. Water permeation drives tumor cell migration in confined microenvironments, Cell 157:1-13 (2014). Selected for F1000Prime Pubmed ID: 24726433
14. K.M. Stroka and K. Konstantopoulos#, Physical cues guide tumor cell adhesion and migration, American Journal of Physiology - Cell Physiology 306: C98-C109 (2014) (Invited review). Pubmed ID: 24133064
2013
13. P.S. Raman*, C.D. Paul*, K.M. Stroka, and K. Konstantopoulos#. Probing cell traction forces in confined microenvironments, Lab on a Chip 13: 4599-4607 (2013). Pubmed ID: 24100608
12. W.C. Hung, S-H Chen, C.D. Paul, K.M. Stroka, J.T. Yang, and K. Konstantopoulos#. Distinct signaling mechanisms for cell migration in unconfined versus confined spaces, Journal of Cell Biology 202(5): 807-824 (2013). Selected for F1000Prime Pubmed ID: 23979717
11. K.M. Stroka, H.N. Hayenga, and H. Aranda-Espinoza#. Biophysical perturbations of neutrophil cytoskeletal dynamics and contractility reduce the efficiency of trans-endothelial migration, PLOS ONE 8(4): e61377 (2013). Pubmed ID: 23626676
10. K.M. Stroka, L.L. Norman, and H. Aranda-Espinoza#. Biomaterial Mechanics, In: Tissue Engineering: Principles and Practices. (Fisher, Mikos, Bronzino, Peterson, eds.) CRC Press, Boca Raton, FL. 14-1 – 14-19 (2013). CRC Press
2012
9. K.M. Stroka#, J.A. Vaitkus, and H. Aranda-Espinoza. Endothelial cells undergo morphological, dynamical, and biomechanical changes in response to TNF-α, European Biophysics Journal 41(11): 939-947 (2012). Pubmed ID: 22940754
8. E.M. Balzer, Z. Tong, C.D. Paul, W.-C. Hung, K.M. Stroka, A.E. Boggs, S.S. Martin, and K. Konstantopoulos#. Physical confinement alters cell adhesion and migration phenotypes, FASEB Journal 26: 1-12 (2012). Pubmed ID: 22707566
7. K.M. Stroka, I. Levitan, and H. Aranda-Espinoza#. OxLDL and substrate stiffness promote neutrophil transmigration through enhanced endothelial cell ICAM-1 and contractility, Journal of Biomechanics 45:1828-1834 (2012). Pubmed ID: 22560286
2011
6. K.M. Stroka and H. Aranda-Espinoza#. Endothelial cell substrate stiffness influences neutrophil transmigration via myosin light chain kinase-dependent cell contraction, Blood 118(6): 1632-1640 (2011). Pubmed ID: 21652678
5. C. Luna, K.M. Stroka, H. Bermudez, and H. Aranda-Espinoza#. Thermodynamics of monolayers formed by mixtures of phosphatidylcholine/phosphatidylserine, Colloids and Surfaces B: Biointerfaces 85: 293-300 (2011). Pubmed ID: 21440423
4. K.M. Stroka and H. Aranda-Espinoza#. Effects of morphology versus cell-cell interactions on endothelial cell stiffness, Cellular and Molecular Bioengineering 4(1): 9-27 (2011). Pubmed ID: 21359128
2010
3. K.M. Stroka# and H. Aranda-Espinoza. A biophysical view of the interplay between mechanical forces and signaling pathways during transendothelial cell migration, FEBS Journal 277: 1145-1158. Flash title on cover of issue (2010). Pubmed ID: 20121945
2009
2. L.L. Norman, K.M. Stroka, and H. Aranda-Espinoza#. Guiding Axons in the Central Nervous System: A Tissue-Engineering Approach, Tissue Eng Part B Rev 15(3): 291-305 (2009) (Invited review). Pubmed ID: 19435403
1. K.M. Stroka and H. Aranda-Espinoza#. Neutrophils display biphasic relationship between migration and substrate stiffness, Cell Motility and Cytoskeleton 66(6): 328-341 (2009). Pubmed ID: 19373775
35. M.T. Doolin*, R.A. Moriarty*, and K.M. Stroka#. Mechanosensing of Physical Confinement by Mesenchymal-Like Cells, Frontiers in Physiology, accepted (2020). (*, equal contribution)
*** invited manuscript for special issue on “Mechanosensing at Biointerfaces.”
34. K.M. Gray, J.W. Jung, C.T. Inglut, H.-C. Huang, and K.M. Stroka#. Quantitatively relating brain endothelial cell-cell junction phenotype to global and local barrier properties under varied culture conditions via the Junction Analyzer Program, Fluids and Barriers of the CNS 17(1): 16 (2020). Link
*** invited manuscript for special issue on "Advances in in vitro modeling of the blood-brain barrier and neurovascular unit."
33. S.P. Ikonomova, P. Moghaddam-Taaherii, Y. Wang, M.T. Doolin, K.M. Stroka, B. Hube, and A.J. Karlsson#. Effects of histatin-5 modifications on antifungal activity and kinetics of proteolysis, Protein Science 29(2): 480-493 (2020). Link
2019
32. M.A. Pranda, B.J. Murugesan, A.J. Knoll, G.S. Oehrlein, and K.M. Stroka#. Sensitivity of tumor vs. normal cell migration and morphology to cold atmospheric plasma-treated media in varying culture conditions, Plasma Processes and Polymers e1900103 (2019). Link
31. Z. Gong, M.T. Doolin, S. Adhikari, K.M. Stroka, A.J. Karlsson#. Role of charge and hydrophobicity in translocation of cell-penetrating peptides into Candida albicans cells, AICheE Journal 65: e16768 (2019). Link.
*** invited manuscript for special issue on “Future of Chemical Engineering.”
30. M.T. Doolin and K.M. Stroka#. Integration of mesenchymal stem cells into a novel micropillar confinement assay, Tissue Engineering Part C: Methods 25(11): 662-676 (2019). Link
*** invited manuscript for special issue on “Methods in Biomechanics and Mechanobiology for Tissue Repair and Regeneration.”
29. M.A. Pranda*, K.M. Gray*, G.M. Dawson, A.J.L. DeCastro, J.W. Jung, and K.M. Stroka#. Tumor cell mechanosensing during incorporation into the brain microvascular endothelium, Cellular and Molecular Bioengineering 12(5):455-480 (2019). (*, equal contribution). Link
*** invited as part of Cellular and Molecular Bioengineering Young Innovator Award special issue.
28. M.T. Doolin*, T.S. Ornstein*, and K.M. Stroka#. Nuclear deformation in response to mechanical confinement is cell type dependent, Cells 8(5): 427 (2019). *, equal contribution) Link
*** invited manuscript for special issue on “Frontiers in Cytoskeleton Research—From Development to Disease.”
27. C. Conrad, K.M. Gray, K.M. Stroka, I. Rizvi, and G. Scarcelli#. Mechanical Characterization of 3D Ovarian Cancer Nodules using Brillouin Confocal Microscopy, Cellular and Molecular Bioengineering 12(3): 215-226 (2019). Link
26. K.M. Gray, D.B. Katz, E.G. Brown, and K.M. Stroka#. Quantitative phenotyping of cell-cell junctions to evaluate ZO-1 presentation in brain endothelial cells, Annals of Biomedical Engineering 47(7): 1675-1687 (2019). Link
2018
25. R.A. Moriarty and K.M. Stroka#. Physical confinement alters sarcoma cell cycle progression and division. Cell Cycle 17(19-20): 2360-2373 (2018). Link
24. M.T. Doolin and K.M. Stroka#. Physical confinement alters cytoskeletal contributions towards human mesenchymal stem cell migration. Cytoskeleton 75:103–117 (2018). Link
*** featured in cover art.
2017
23. M.A. Shumakovich, C.P. Mencio, J.S. Siglin, R.A. Moriarty, H.M. Geller, and K.M. Stroka#. Astrocytes from the brain microenvironment alter migration and morphology of metastatic breast cancer cells, FASEB Journal 31:115049-5067 (2017). Link
22. K.M. Gray and K.M. Stroka#. Vascular endothelial cell mechanosensing: New insights gained from biomimetic microfluidic models, Seminars in Cell and Developmental Biology 71:106-117 (2017). Link
*** invited review article for special issue on “Mechanosensing: from Molecules to Tissues”
21. D.B. Patel*, K.M. Gray*, Y. Santharam, K.M. Stroka#, S.M. Jay#. Effects of cell seeding density and passage number on mesenchymal stem cell exosome biogenesis and vascularization activity, Bioengineering and Translational Medicine, 2:170-179 (2017). Link
20. K.M. Stroka#, B.S. Wong, M. Shriver, J.M. Phillip, D. Wirtz, A. Kontrogianni, and K. Konstantopoulos#. Loss of giant obscurins alters breast epithelial cell mechanosensing of matrix stiffness, Oncotarget 8:54004-54020 (2017). Pubmed ID: 27494856
2015
19. M. Shriver, K.M. Stroka, M. Vitolo, S.S. Martin, D. Huso, K. Konstantopoulos, and A. Kontrogianni#. Loss of giant obscurins from breast epithelium promotes cell migration, invasion, and metastasis, Oncogene 34:4248-4259 (2015). Pubmed ID: 25381817
18. K.M. Stroka#. Leukocyte trans-endothelial migration: A biophysical event. In: Mechanobiology of the Endothelium. (Aranda-Espinoza, ed.) CRC Press, Boca Raton, FL. (2015). CRC Press
2014
17. S. Hamilla*, K.M. Stroka*, and H. Aranda-Espinoza#. VE-cadherin-independent cancer cell incorporation into the vascular endothelium precedes transmigration, PLOS ONE 9(10): e109748 (2014). Pubmed ID: 25275457
16. K.M. Stroka, Z.Gu, S.X. Sun, and K. Konstantopoulos#. Bioengineering paradigms for cell migration in confined microenvironments Current Opinion in Cell Biology 30C: 41-50 (2014) (Invited review). Pubmed ID: 24973724
15. K.M. Stroka*, H. Jiang*, S-H Chen, Z. Tong, D. Wirtz, S.X. Sun#, and K. Konstantopoulos#. Water permeation drives tumor cell migration in confined microenvironments, Cell 157:1-13 (2014). Selected for F1000Prime Pubmed ID: 24726433
14. K.M. Stroka and K. Konstantopoulos#, Physical cues guide tumor cell adhesion and migration, American Journal of Physiology - Cell Physiology 306: C98-C109 (2014) (Invited review). Pubmed ID: 24133064
2013
13. P.S. Raman*, C.D. Paul*, K.M. Stroka, and K. Konstantopoulos#. Probing cell traction forces in confined microenvironments, Lab on a Chip 13: 4599-4607 (2013). Pubmed ID: 24100608
12. W.C. Hung, S-H Chen, C.D. Paul, K.M. Stroka, J.T. Yang, and K. Konstantopoulos#. Distinct signaling mechanisms for cell migration in unconfined versus confined spaces, Journal of Cell Biology 202(5): 807-824 (2013). Selected for F1000Prime Pubmed ID: 23979717
11. K.M. Stroka, H.N. Hayenga, and H. Aranda-Espinoza#. Biophysical perturbations of neutrophil cytoskeletal dynamics and contractility reduce the efficiency of trans-endothelial migration, PLOS ONE 8(4): e61377 (2013). Pubmed ID: 23626676
10. K.M. Stroka, L.L. Norman, and H. Aranda-Espinoza#. Biomaterial Mechanics, In: Tissue Engineering: Principles and Practices. (Fisher, Mikos, Bronzino, Peterson, eds.) CRC Press, Boca Raton, FL. 14-1 – 14-19 (2013). CRC Press
2012
9. K.M. Stroka#, J.A. Vaitkus, and H. Aranda-Espinoza. Endothelial cells undergo morphological, dynamical, and biomechanical changes in response to TNF-α, European Biophysics Journal 41(11): 939-947 (2012). Pubmed ID: 22940754
8. E.M. Balzer, Z. Tong, C.D. Paul, W.-C. Hung, K.M. Stroka, A.E. Boggs, S.S. Martin, and K. Konstantopoulos#. Physical confinement alters cell adhesion and migration phenotypes, FASEB Journal 26: 1-12 (2012). Pubmed ID: 22707566
7. K.M. Stroka, I. Levitan, and H. Aranda-Espinoza#. OxLDL and substrate stiffness promote neutrophil transmigration through enhanced endothelial cell ICAM-1 and contractility, Journal of Biomechanics 45:1828-1834 (2012). Pubmed ID: 22560286
2011
6. K.M. Stroka and H. Aranda-Espinoza#. Endothelial cell substrate stiffness influences neutrophil transmigration via myosin light chain kinase-dependent cell contraction, Blood 118(6): 1632-1640 (2011). Pubmed ID: 21652678
5. C. Luna, K.M. Stroka, H. Bermudez, and H. Aranda-Espinoza#. Thermodynamics of monolayers formed by mixtures of phosphatidylcholine/phosphatidylserine, Colloids and Surfaces B: Biointerfaces 85: 293-300 (2011). Pubmed ID: 21440423
4. K.M. Stroka and H. Aranda-Espinoza#. Effects of morphology versus cell-cell interactions on endothelial cell stiffness, Cellular and Molecular Bioengineering 4(1): 9-27 (2011). Pubmed ID: 21359128
2010
3. K.M. Stroka# and H. Aranda-Espinoza. A biophysical view of the interplay between mechanical forces and signaling pathways during transendothelial cell migration, FEBS Journal 277: 1145-1158. Flash title on cover of issue (2010). Pubmed ID: 20121945
2009
2. L.L. Norman, K.M. Stroka, and H. Aranda-Espinoza#. Guiding Axons in the Central Nervous System: A Tissue-Engineering Approach, Tissue Eng Part B Rev 15(3): 291-305 (2009) (Invited review). Pubmed ID: 19435403
1. K.M. Stroka and H. Aranda-Espinoza#. Neutrophils display biphasic relationship between migration and substrate stiffness, Cell Motility and Cytoskeleton 66(6): 328-341 (2009). Pubmed ID: 19373775