Publications
2021
42. Y. Yan#, R.A. Moriarty, and K.M. Stroka#. Recent progress and new challenges in modeling of human pluripotent stem cell-derived blood-brain barrier. Theranostics (accepted, 2021). #co-corresponding author
41. R.A. Moriarty, S. Mili#, K.M. Stroka#. RNA localization in confined cells depends on cellular mechanical activity and contributes to confined migration. iScience - Cell Press Sneak Peek (2021) Link
40. T.B. Gagliardi, M.E. Goldstein, D. Song, K.M. Gray, J.W. Jung, K.M. Stroka, G.A. Duncan, M.A. Scull#. Rhinovirus C replication is associated with the endoplasmic reticulum and triggers cytopathic effects in an in vitro model of human airway epithelium. bioRxiv (2021). Link
2020
39. C.T. Inglut, K.M. Gray, S. Vig, J.W. Jung, J. Stabile, Y. Zhang, K.M. Stroka, Huang-Chiao Huang#. Photodynamic Priming Modulates Endothelial Cell–Cell Junction Phenotype for Light-activated Remote Control of Drug Delivery.
Journal of Selected Topics in Quantum Electronics (2020). Link
*** invited manuscript for special issue on “Biophotonics.”
38. K.M. Stroka#. Swimming cells can stay in shape (New and Notable), Biophysical Journal 119(6): 1048-1049 (2020). Link
37. M.A. Pranda and K.M. Stroka#, “Modeling the roles of astrocytes in the metastatic tumor cell microenvironment,” chapter to appear in “Tumor Microenvironment – Novel Concepts” volume of “Advances in Experimental Medicine and Biology.” (accepted, 2020).
36. J. Li, K.M. Gray, E. Kim, C. Conrad, C.-Y. Tsao, S.P. Wang, G. Zong, G. Scarcelli, K.M. Stroka, L. Wang, W.E. Bentley, and G.F. Payne#. Mediated electrochemistry to mimic biology’s oxidative assembly of functional matrices, Advanced Functional Materials, in press (2020). Link
35. M.T. Doolin*, R.A. Moriarty*, and K.M. Stroka#. Mechanosensing of Physical Confinement by Mesenchymal-Like Cells, Frontiers in Physiology 11:365 (2020). (*, equal contribution). Link
*** invited manuscript for special issue on “Mechanosensing at Biointerfaces.”
34. K.M. Gray, J.W. Jung, C.T. Inglut, H.-C. Huang, and K.M. Stroka#. Quantitatively relating brain endothelial cell-cell junction phenotype to global and local barrier properties under varied culture conditions via the Junction Analyzer Program, Fluids and Barriers of the CNS 17(1): 16 (2020). Link
*** invited manuscript for special issue on "Advances in in vitro modeling of the blood-brain barrier and neurovascular unit."
33. S.P. Ikonomova, P. Moghaddam-Taaherii, Y. Wang, M.T. Doolin, K.M. Stroka, B. Hube, and A.J. Karlsson#. Effects of histatin-5 modifications on antifungal activity and kinetics of proteolysis, Protein Science 29(2): 480-493 (2020). Link
32. M.A. Pranda, B.J. Murugesan, A.J. Knoll, G.S. Oehrlein, and K.M. Stroka#. Sensitivity of tumor vs. normal cell migration and morphology to cold atmospheric plasma-treated media in varying culture conditions, Plasma Processes and Polymers e1900103 (2020). Link
2019
31. Z. Gong, M.T. Doolin, S. Adhikari, K.M. Stroka, A.J. Karlsson#. Role of charge and hydrophobicity in translocation of cell-penetrating peptides into Candida albicans cells, AICheE Journal 65: e16768 (2019). Link.
*** invited manuscript for special issue on “Future of Chemical Engineering.”
30. M.T. Doolin and K.M. Stroka#. Integration of mesenchymal stem cells into a novel micropillar confinement assay, Tissue Engineering Part C: Methods 25(11): 662-676 (2019). Link
*** invited manuscript for special issue on “Methods in Biomechanics and Mechanobiology for Tissue Repair and Regeneration.”
29. M.A. Pranda*, K.M. Gray*, G.M. Dawson, A.J.L. DeCastro, J.W. Jung, and K.M. Stroka#. Tumor cell mechanosensing during incorporation into the brain microvascular endothelium, Cellular and Molecular Bioengineering 12(5):455-480 (2019). (*, equal contribution). Link
*** invited as part of Cellular and Molecular Bioengineering Young Innovator Award special issue.
28. M.T. Doolin*, T.S. Ornstein*, and K.M. Stroka#. Nuclear deformation in response to mechanical confinement is cell type dependent, Cells 8(5): 427 (2019). *, equal contribution) Link
*** invited manuscript for special issue on “Frontiers in Cytoskeleton Research—From Development to Disease.”
27. C. Conrad, K.M. Gray, K.M. Stroka, I. Rizvi, and G. Scarcelli#. Mechanical Characterization of 3D Ovarian Cancer Nodules using Brillouin Confocal Microscopy, Cellular and Molecular Bioengineering 12(3): 215-226 (2019). Link
26. K.M. Gray, D.B. Katz, E.G. Brown, and K.M. Stroka#. Quantitative phenotyping of cell-cell junctions to evaluate ZO-1 presentation in brain endothelial cells, Annals of Biomedical Engineering 47(7): 1675-1687 (2019). Link
2018
25. R.A. Moriarty and K.M. Stroka#. Physical confinement alters sarcoma cell cycle progression and division. Cell Cycle 17(19-20): 2360-2373 (2018). Link
24. M.T. Doolin and K.M. Stroka#. Physical confinement alters cytoskeletal contributions towards human mesenchymal stem cell migration. Cytoskeleton 75:103–117 (2018). Link
*** featured in cover art.
2017
23. M.A. Shumakovich, C.P. Mencio, J.S. Siglin, R.A. Moriarty, H.M. Geller, and K.M. Stroka#. Astrocytes from the brain microenvironment alter migration and morphology of metastatic breast cancer cells, FASEB Journal 31:115049-5067 (2017). Link
22. K.M. Gray and K.M. Stroka#. Vascular endothelial cell mechanosensing: New insights gained from biomimetic microfluidic models, Seminars in Cell and Developmental Biology 71:106-117 (2017). Link
*** invited review article for special issue on “Mechanosensing: from Molecules to Tissues”
21. D.B. Patel*, K.M. Gray*, Y. Santharam, K.M. Stroka#, S.M. Jay#. Effects of cell seeding density and passage number on mesenchymal stem cell exosome biogenesis and vascularization activity, Bioengineering and Translational Medicine, 2:170-179 (2017). Link
20. K.M. Stroka#, B.S. Wong, M. Shriver, J.M. Phillip, D. Wirtz, A. Kontrogianni, and K. Konstantopoulos#. Loss of giant obscurins alters breast epithelial cell mechanosensing of matrix stiffness, Oncotarget 8:54004-54020 (2017). Pubmed ID: 27494856
2015
19. M. Shriver, K.M. Stroka, M. Vitolo, S.S. Martin, D. Huso, K. Konstantopoulos, and A. Kontrogianni#. Loss of giant obscurins from breast epithelium promotes cell migration, invasion, and metastasis, Oncogene 34:4248-4259 (2015). Pubmed ID: 25381817
18. K.M. Stroka#. Leukocyte trans-endothelial migration: A biophysical event. In: Mechanobiology of the Endothelium. (Aranda-Espinoza, ed.) CRC Press, Boca Raton, FL. (2015). CRC Press
2014
17. S. Hamilla*, K.M. Stroka*, and H. Aranda-Espinoza#. VE-cadherin-independent cancer cell incorporation into the vascular endothelium precedes transmigration, PLOS ONE 9(10): e109748 (2014). Pubmed ID: 25275457
16. K.M. Stroka, Z.Gu, S.X. Sun, and K. Konstantopoulos#. Bioengineering paradigms for cell migration in confined microenvironments Current Opinion in Cell Biology 30C: 41-50 (2014) (Invited review). Pubmed ID: 24973724
15. K.M. Stroka*, H. Jiang*, S-H Chen, Z. Tong, D. Wirtz, S.X. Sun#, and K. Konstantopoulos#. Water permeation drives tumor cell migration in confined microenvironments, Cell 157:1-13 (2014). Selected for F1000Prime Pubmed ID: 24726433
14. K.M. Stroka and K. Konstantopoulos#, Physical cues guide tumor cell adhesion and migration, American Journal of Physiology - Cell Physiology 306: C98-C109 (2014) (Invited review). Pubmed ID: 24133064
2013
13. P.S. Raman*, C.D. Paul*, K.M. Stroka, and K. Konstantopoulos#. Probing cell traction forces in confined microenvironments, Lab on a Chip 13: 4599-4607 (2013). Pubmed ID: 24100608
12. W.C. Hung, S-H Chen, C.D. Paul, K.M. Stroka, J.T. Yang, and K. Konstantopoulos#. Distinct signaling mechanisms for cell migration in unconfined versus confined spaces, Journal of Cell Biology 202(5): 807-824 (2013). Selected for F1000Prime Pubmed ID: 23979717
11. K.M. Stroka, H.N. Hayenga, and H. Aranda-Espinoza#. Biophysical perturbations of neutrophil cytoskeletal dynamics and contractility reduce the efficiency of trans-endothelial migration, PLOS ONE 8(4): e61377 (2013). Pubmed ID: 23626676
10. K.M. Stroka, L.L. Norman, and H. Aranda-Espinoza#. Biomaterial Mechanics, In: Tissue Engineering: Principles and Practices. (Fisher, Mikos, Bronzino, Peterson, eds.) CRC Press, Boca Raton, FL. 14-1 – 14-19 (2013). CRC Press
2012
9. K.M. Stroka#, J.A. Vaitkus, and H. Aranda-Espinoza. Endothelial cells undergo morphological, dynamical, and biomechanical changes in response to TNF-α, European Biophysics Journal 41(11): 939-947 (2012). Pubmed ID: 22940754
8. E.M. Balzer, Z. Tong, C.D. Paul, W.-C. Hung, K.M. Stroka, A.E. Boggs, S.S. Martin, and K. Konstantopoulos#. Physical confinement alters cell adhesion and migration phenotypes, FASEB Journal 26: 1-12 (2012). Pubmed ID: 22707566
7. K.M. Stroka, I. Levitan, and H. Aranda-Espinoza#. OxLDL and substrate stiffness promote neutrophil transmigration through enhanced endothelial cell ICAM-1 and contractility, Journal of Biomechanics 45:1828-1834 (2012). Pubmed ID: 22560286
2011
6. K.M. Stroka and H. Aranda-Espinoza#. Endothelial cell substrate stiffness influences neutrophil transmigration via myosin light chain kinase-dependent cell contraction, Blood 118(6): 1632-1640 (2011). Pubmed ID: 21652678
5. C. Luna, K.M. Stroka, H. Bermudez, and H. Aranda-Espinoza#. Thermodynamics of monolayers formed by mixtures of phosphatidylcholine/phosphatidylserine, Colloids and Surfaces B: Biointerfaces 85: 293-300 (2011). Pubmed ID: 21440423
4. K.M. Stroka and H. Aranda-Espinoza#. Effects of morphology versus cell-cell interactions on endothelial cell stiffness, Cellular and Molecular Bioengineering 4(1): 9-27 (2011). Pubmed ID: 21359128
2010
3. K.M. Stroka# and H. Aranda-Espinoza. A biophysical view of the interplay between mechanical forces and signaling pathways during transendothelial cell migration, FEBS Journal 277: 1145-1158. Flash title on cover of issue (2010). Pubmed ID: 20121945
2009
2. L.L. Norman, K.M. Stroka, and H. Aranda-Espinoza#. Guiding Axons in the Central Nervous System: A Tissue-Engineering Approach, Tissue Eng Part B Rev 15(3): 291-305 (2009) (Invited review). Pubmed ID: 19435403
1. K.M. Stroka and H. Aranda-Espinoza#. Neutrophils display biphasic relationship between migration and substrate stiffness, Cell Motility and Cytoskeleton 66(6): 328-341 (2009). Pubmed ID: 19373775
42. Y. Yan#, R.A. Moriarty, and K.M. Stroka#. Recent progress and new challenges in modeling of human pluripotent stem cell-derived blood-brain barrier. Theranostics (accepted, 2021). #co-corresponding author
41. R.A. Moriarty, S. Mili#, K.M. Stroka#. RNA localization in confined cells depends on cellular mechanical activity and contributes to confined migration. iScience - Cell Press Sneak Peek (2021) Link
40. T.B. Gagliardi, M.E. Goldstein, D. Song, K.M. Gray, J.W. Jung, K.M. Stroka, G.A. Duncan, M.A. Scull#. Rhinovirus C replication is associated with the endoplasmic reticulum and triggers cytopathic effects in an in vitro model of human airway epithelium. bioRxiv (2021). Link
2020
39. C.T. Inglut, K.M. Gray, S. Vig, J.W. Jung, J. Stabile, Y. Zhang, K.M. Stroka, Huang-Chiao Huang#. Photodynamic Priming Modulates Endothelial Cell–Cell Junction Phenotype for Light-activated Remote Control of Drug Delivery.
Journal of Selected Topics in Quantum Electronics (2020). Link
*** invited manuscript for special issue on “Biophotonics.”
38. K.M. Stroka#. Swimming cells can stay in shape (New and Notable), Biophysical Journal 119(6): 1048-1049 (2020). Link
37. M.A. Pranda and K.M. Stroka#, “Modeling the roles of astrocytes in the metastatic tumor cell microenvironment,” chapter to appear in “Tumor Microenvironment – Novel Concepts” volume of “Advances in Experimental Medicine and Biology.” (accepted, 2020).
36. J. Li, K.M. Gray, E. Kim, C. Conrad, C.-Y. Tsao, S.P. Wang, G. Zong, G. Scarcelli, K.M. Stroka, L. Wang, W.E. Bentley, and G.F. Payne#. Mediated electrochemistry to mimic biology’s oxidative assembly of functional matrices, Advanced Functional Materials, in press (2020). Link
35. M.T. Doolin*, R.A. Moriarty*, and K.M. Stroka#. Mechanosensing of Physical Confinement by Mesenchymal-Like Cells, Frontiers in Physiology 11:365 (2020). (*, equal contribution). Link
*** invited manuscript for special issue on “Mechanosensing at Biointerfaces.”
34. K.M. Gray, J.W. Jung, C.T. Inglut, H.-C. Huang, and K.M. Stroka#. Quantitatively relating brain endothelial cell-cell junction phenotype to global and local barrier properties under varied culture conditions via the Junction Analyzer Program, Fluids and Barriers of the CNS 17(1): 16 (2020). Link
*** invited manuscript for special issue on "Advances in in vitro modeling of the blood-brain barrier and neurovascular unit."
33. S.P. Ikonomova, P. Moghaddam-Taaherii, Y. Wang, M.T. Doolin, K.M. Stroka, B. Hube, and A.J. Karlsson#. Effects of histatin-5 modifications on antifungal activity and kinetics of proteolysis, Protein Science 29(2): 480-493 (2020). Link
32. M.A. Pranda, B.J. Murugesan, A.J. Knoll, G.S. Oehrlein, and K.M. Stroka#. Sensitivity of tumor vs. normal cell migration and morphology to cold atmospheric plasma-treated media in varying culture conditions, Plasma Processes and Polymers e1900103 (2020). Link
2019
31. Z. Gong, M.T. Doolin, S. Adhikari, K.M. Stroka, A.J. Karlsson#. Role of charge and hydrophobicity in translocation of cell-penetrating peptides into Candida albicans cells, AICheE Journal 65: e16768 (2019). Link.
*** invited manuscript for special issue on “Future of Chemical Engineering.”
30. M.T. Doolin and K.M. Stroka#. Integration of mesenchymal stem cells into a novel micropillar confinement assay, Tissue Engineering Part C: Methods 25(11): 662-676 (2019). Link
*** invited manuscript for special issue on “Methods in Biomechanics and Mechanobiology for Tissue Repair and Regeneration.”
29. M.A. Pranda*, K.M. Gray*, G.M. Dawson, A.J.L. DeCastro, J.W. Jung, and K.M. Stroka#. Tumor cell mechanosensing during incorporation into the brain microvascular endothelium, Cellular and Molecular Bioengineering 12(5):455-480 (2019). (*, equal contribution). Link
*** invited as part of Cellular and Molecular Bioengineering Young Innovator Award special issue.
28. M.T. Doolin*, T.S. Ornstein*, and K.M. Stroka#. Nuclear deformation in response to mechanical confinement is cell type dependent, Cells 8(5): 427 (2019). *, equal contribution) Link
*** invited manuscript for special issue on “Frontiers in Cytoskeleton Research—From Development to Disease.”
27. C. Conrad, K.M. Gray, K.M. Stroka, I. Rizvi, and G. Scarcelli#. Mechanical Characterization of 3D Ovarian Cancer Nodules using Brillouin Confocal Microscopy, Cellular and Molecular Bioengineering 12(3): 215-226 (2019). Link
26. K.M. Gray, D.B. Katz, E.G. Brown, and K.M. Stroka#. Quantitative phenotyping of cell-cell junctions to evaluate ZO-1 presentation in brain endothelial cells, Annals of Biomedical Engineering 47(7): 1675-1687 (2019). Link
2018
25. R.A. Moriarty and K.M. Stroka#. Physical confinement alters sarcoma cell cycle progression and division. Cell Cycle 17(19-20): 2360-2373 (2018). Link
24. M.T. Doolin and K.M. Stroka#. Physical confinement alters cytoskeletal contributions towards human mesenchymal stem cell migration. Cytoskeleton 75:103–117 (2018). Link
*** featured in cover art.
2017
23. M.A. Shumakovich, C.P. Mencio, J.S. Siglin, R.A. Moriarty, H.M. Geller, and K.M. Stroka#. Astrocytes from the brain microenvironment alter migration and morphology of metastatic breast cancer cells, FASEB Journal 31:115049-5067 (2017). Link
22. K.M. Gray and K.M. Stroka#. Vascular endothelial cell mechanosensing: New insights gained from biomimetic microfluidic models, Seminars in Cell and Developmental Biology 71:106-117 (2017). Link
*** invited review article for special issue on “Mechanosensing: from Molecules to Tissues”
21. D.B. Patel*, K.M. Gray*, Y. Santharam, K.M. Stroka#, S.M. Jay#. Effects of cell seeding density and passage number on mesenchymal stem cell exosome biogenesis and vascularization activity, Bioengineering and Translational Medicine, 2:170-179 (2017). Link
20. K.M. Stroka#, B.S. Wong, M. Shriver, J.M. Phillip, D. Wirtz, A. Kontrogianni, and K. Konstantopoulos#. Loss of giant obscurins alters breast epithelial cell mechanosensing of matrix stiffness, Oncotarget 8:54004-54020 (2017). Pubmed ID: 27494856
2015
19. M. Shriver, K.M. Stroka, M. Vitolo, S.S. Martin, D. Huso, K. Konstantopoulos, and A. Kontrogianni#. Loss of giant obscurins from breast epithelium promotes cell migration, invasion, and metastasis, Oncogene 34:4248-4259 (2015). Pubmed ID: 25381817
18. K.M. Stroka#. Leukocyte trans-endothelial migration: A biophysical event. In: Mechanobiology of the Endothelium. (Aranda-Espinoza, ed.) CRC Press, Boca Raton, FL. (2015). CRC Press
2014
17. S. Hamilla*, K.M. Stroka*, and H. Aranda-Espinoza#. VE-cadherin-independent cancer cell incorporation into the vascular endothelium precedes transmigration, PLOS ONE 9(10): e109748 (2014). Pubmed ID: 25275457
16. K.M. Stroka, Z.Gu, S.X. Sun, and K. Konstantopoulos#. Bioengineering paradigms for cell migration in confined microenvironments Current Opinion in Cell Biology 30C: 41-50 (2014) (Invited review). Pubmed ID: 24973724
15. K.M. Stroka*, H. Jiang*, S-H Chen, Z. Tong, D. Wirtz, S.X. Sun#, and K. Konstantopoulos#. Water permeation drives tumor cell migration in confined microenvironments, Cell 157:1-13 (2014). Selected for F1000Prime Pubmed ID: 24726433
14. K.M. Stroka and K. Konstantopoulos#, Physical cues guide tumor cell adhesion and migration, American Journal of Physiology - Cell Physiology 306: C98-C109 (2014) (Invited review). Pubmed ID: 24133064
2013
13. P.S. Raman*, C.D. Paul*, K.M. Stroka, and K. Konstantopoulos#. Probing cell traction forces in confined microenvironments, Lab on a Chip 13: 4599-4607 (2013). Pubmed ID: 24100608
12. W.C. Hung, S-H Chen, C.D. Paul, K.M. Stroka, J.T. Yang, and K. Konstantopoulos#. Distinct signaling mechanisms for cell migration in unconfined versus confined spaces, Journal of Cell Biology 202(5): 807-824 (2013). Selected for F1000Prime Pubmed ID: 23979717
11. K.M. Stroka, H.N. Hayenga, and H. Aranda-Espinoza#. Biophysical perturbations of neutrophil cytoskeletal dynamics and contractility reduce the efficiency of trans-endothelial migration, PLOS ONE 8(4): e61377 (2013). Pubmed ID: 23626676
10. K.M. Stroka, L.L. Norman, and H. Aranda-Espinoza#. Biomaterial Mechanics, In: Tissue Engineering: Principles and Practices. (Fisher, Mikos, Bronzino, Peterson, eds.) CRC Press, Boca Raton, FL. 14-1 – 14-19 (2013). CRC Press
2012
9. K.M. Stroka#, J.A. Vaitkus, and H. Aranda-Espinoza. Endothelial cells undergo morphological, dynamical, and biomechanical changes in response to TNF-α, European Biophysics Journal 41(11): 939-947 (2012). Pubmed ID: 22940754
8. E.M. Balzer, Z. Tong, C.D. Paul, W.-C. Hung, K.M. Stroka, A.E. Boggs, S.S. Martin, and K. Konstantopoulos#. Physical confinement alters cell adhesion and migration phenotypes, FASEB Journal 26: 1-12 (2012). Pubmed ID: 22707566
7. K.M. Stroka, I. Levitan, and H. Aranda-Espinoza#. OxLDL and substrate stiffness promote neutrophil transmigration through enhanced endothelial cell ICAM-1 and contractility, Journal of Biomechanics 45:1828-1834 (2012). Pubmed ID: 22560286
2011
6. K.M. Stroka and H. Aranda-Espinoza#. Endothelial cell substrate stiffness influences neutrophil transmigration via myosin light chain kinase-dependent cell contraction, Blood 118(6): 1632-1640 (2011). Pubmed ID: 21652678
5. C. Luna, K.M. Stroka, H. Bermudez, and H. Aranda-Espinoza#. Thermodynamics of monolayers formed by mixtures of phosphatidylcholine/phosphatidylserine, Colloids and Surfaces B: Biointerfaces 85: 293-300 (2011). Pubmed ID: 21440423
4. K.M. Stroka and H. Aranda-Espinoza#. Effects of morphology versus cell-cell interactions on endothelial cell stiffness, Cellular and Molecular Bioengineering 4(1): 9-27 (2011). Pubmed ID: 21359128
2010
3. K.M. Stroka# and H. Aranda-Espinoza. A biophysical view of the interplay between mechanical forces and signaling pathways during transendothelial cell migration, FEBS Journal 277: 1145-1158. Flash title on cover of issue (2010). Pubmed ID: 20121945
2009
2. L.L. Norman, K.M. Stroka, and H. Aranda-Espinoza#. Guiding Axons in the Central Nervous System: A Tissue-Engineering Approach, Tissue Eng Part B Rev 15(3): 291-305 (2009) (Invited review). Pubmed ID: 19435403
1. K.M. Stroka and H. Aranda-Espinoza#. Neutrophils display biphasic relationship between migration and substrate stiffness, Cell Motility and Cytoskeleton 66(6): 328-341 (2009). Pubmed ID: 19373775